PO-02-245 THE IMPACT OF PULSED FIELD ABLATION ON CONDUCTION VELOCITY OVER TIME

Pulsed field ablation (PFA) is an emerging technology that has both reversible and irreversible effects. However, the time course of reversibility atrial conduction velocity after PFA not been well characterized. To determine changes in over Nine pigs were studied. The Medtronic PVAC GOLD catheter was placed superior vena cava (SVC), right atrium (RA), left appendage (LAA) pulmonary vein (LPV). One four trains at 1000 V 1500V delivered these sites a random fashion. Activation mapping done baseline 10-20 minute intervals post using ESI system. Conduction obtained between site entry exit identified by wavefront propagation scar 5-minute point ablation. Regional slowing defined as <31 cm/s recovery studied 120 minutes point. Recovery 50% compared to 5 >100 across all experimental conditions. At 1000V x 1 4 application, average 21[HDM1] ±9 44 ±30 respectively. 27 ±16 33 ±15 lowest occurred (31 (5-100 cm/s). 2/8 animals recovered min 4, 1/8 0/8 Median 72 (25-160 min). (Figure 1) observed PFA, more often with lower voltage ablations this porcine model. exceeds standard clinical wait suggesting retesting for block 20 may be limited value.